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Nitric Oxide in Plasma (by Chemical Luminescence)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of nitric oxide, a naturally occurring chemical produced by your body that helps regulate blood flow and blood pressure.

Quick summary

["Nitric oxide helps maintain healthy circulation and may be checked if you have concerns about vascular health or certain conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
33762-6
Short code
NT-proBNP SerPl-mCnc
Synonyms
NT-proBNP SerPl-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83880
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Nitric oxide is produced by cells in your body, primarily in the lining of blood vessels. It helps relax blood vessel walls, improving blood flow and maintaining healthy circulation. This test measures the concentration of nitric oxide in your plasma, which can reflect your body’s ability to produce and use this chemical.

Why Might This Test Be Ordered?

A doctor may order this test if you have symptoms or risk factors related to poor circulation, such as high blood pressure, heart disease, or conditions affecting blood vessel function. It may also be part of a broader evaluation for vascular health or certain inflammatory or autoimmune conditions.

Sample Collection and Preparation

For this test, a small amount of blood is drawn from a vein in your arm. The blood is processed to separate the plasma, which is then analyzed for nitric oxide levels. This process typically takes a few minutes, and you may feel a brief pinch during the draw.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to avoid certain medications or supplements that could affect nitric oxide levels, such as some blood pressure medications or herbal supplements. Always inform your healthcare provider about all medications you are taking.

Reference range

Normal: <100 pg/mLN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Plasma Nitric Oxide Level

Frequently asked questions

How is nitric oxide tested, and what does it involve?
Nitric oxide is measured using a specialized chemical luminescence method. After your blood is drawn, it is analyzed in a lab to detect the presence of nitric oxide. This test does not require fasting or special diet restrictions, but your healthcare provider may advise against certain medications that could influence results.
What are the typical reference ranges for nitric oxide?
Reference ranges for nitric oxide can vary by lab and individual factors. Your results will be compared to ranges specific to your healthcare provider’s lab and your unique health profile. Always discuss your results with your doctor, as they will interpret them in the context of your overall health.
Can lifestyle changes affect nitric oxide levels?
Yes, lifestyle factors such as diet (e.g., Mediterranean diet rich in antioxidants), exercise, and managing stress can influence nitric oxide production. Quitting smoking, maintaining healthy blood pressure, and avoiding excessive alcohol may support healthier nitric oxide levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy