Neurotrophic Receptor Tyrosine Kinase (NTRK1, NTRK2, NTRK3) Mutation Analysis
This test checks for specific genetic changes (mutations) in the NTRK genes, which are involved in cell growth and development. These mutations can be linked to certain cancers or other rare conditions.
This test helps identify genetic variations that may influence cancer risk or response to targeted therapies.
Key facts at a glance
- LOINC
- 105596-1
- Short code
- NTRK1 & NTRK2 & NTRK3 targ mut anl Tiss
- Synonyms
- NTRK1 & NTRK2 & NTRK3 targ mut anl Tiss
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a type of cancer (such as certain solid tumors) where NTRK gene mutations are known to play a role. It could also be used in research or for patients with rare genetic disorders linked to these genes.
What the Test Involves
A small sample of tissue (such as a tumor biopsy) or blood may be collected for testing. The test analyzes DNA to detect mutations in the NTRK1, NTRK2, or NTRK3 genes. Results help determine if targeted treatments could be effective.
What the Results Mean
If mutations are found, they may indicate a potential response to specific therapies designed to target these genetic changes. If no mutations are detected, it may help guide treatment decisions differently.
Common Uses in Clinical Care
This test is primarily used in oncology to guide treatment planning for cancers where NTRK mutations are clinically relevant, such as certain types of neuroendocrine tumors or sarcomas. It may also be part of broader genetic testing for inherited conditions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
NTRK gene mutations can drive tumor growth in some cancers. Detecting these mutations helps clinicians select therapies that specifically inhibit these pathways, potentially improving outcomes. However, results should be interpreted alongside clinical findings and other diagnostic tests.
Short name
NTRK Gene Mutation Test
Frequently asked questions
What does a positive result mean?
How long does it take to get results?
Are there any risks or side effects from this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy