Skip to content

Cerebrospinal Fluid Cell Count with Differential (Manual Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number and types of cells in your cerebrospinal fluid (CSF), which surrounds your brain and spinal cord. It helps identify infections, inflammation, or other conditions affecting these fluids.

Quick summary

["A CSF cell count helps diagnose neurological issues by examining cell types and counts in your spinal fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72330-4
Short code
Nuc cell/Rnd cells NFr Smn Manual
Synonyms
Nuc cell/Rnd cells NFr Smn Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It can help determine if there’s an infection (like meningitis), bleeding, or other issues causing changes in your CSF.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) where a small needle is inserted into your lower back to collect CSF. The procedure is quick but may cause mild discomfort. No special preparation is needed, but inform your provider about any medications or allergies.

What the Results Mean

The test looks at white blood cells (like lymphocytes or neutrophils), red blood cells, and other cells. High white blood cells often suggest infection or inflammation, while red blood cells may indicate bleeding. Your provider will interpret results based on your symptoms and overall health.

Common Conditions This Test Helps Diagnose

This test is key for diagnosing conditions like bacterial or viral meningitis, multiple sclerosis, brain tumors, or bleeding disorders. It can also help monitor treatment progress or rule out other neurological issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CSF Cell Count

Frequently asked questions

How long will I need to wait for my results?
Results are typically available within 24 to 48 hours, depending on lab processing. Your provider will discuss them with you during a follow-up visit.
Can I eat or drink before this test?
No special diet is required, but avoid caffeine or heavy meals before the procedure to reduce discomfort. Hydration is fine unless instructed otherwise.
Will the test hurt?
The procedure itself is brief but may cause a mild sting or pressure. Most people describe it as similar to a blood draw, though some feel slight back discomfort afterward.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy