Protein Immunoblot for Nuclear Pore Proteins (Specifically P210) with Immunoglobulin G (IgG) Detection
This test measures antibodies against specific nuclear pore proteins (including P210) in your blood, which may help identify certain autoimmune conditions.
["This test helps assess potential autoimmune responses to nuclear pore components."]
Key facts at a glance
- LOINC
- 82931-7
- Short code
- Nucl pore prot gp210 IgG Ser Ql Ln blot
- Synonyms
- Nucl pore prot gp210 IgG Ser Ql Ln blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or conditions linked to autoimmune diseases affecting nuclear pore proteins, such as systemic lupus erythematosus (SLE) or other connective tissue disorders. It may also be used in research or specialized diagnostic contexts for rare autoimmune conditions.
What to Expect Before the Test
No special preparation is typically needed. You may donate blood in the morning or afternoon, depending on your clinic’s schedule. Avoid alcohol for 24 hours before testing if instructed.
How the Test Works
A small blood sample is drawn, and the serum is analyzed using a specialized immunoblotting technique. This detects IgG antibodies against nuclear pore proteins, including P210, by comparing them to known standards.
What the Results Mean
Results are qualitative (positive or negative) and indicate whether IgG antibodies are present against these proteins. Elevated or abnormal levels may suggest an autoimmune response, but results alone do not diagnose a condition. They are often used alongside clinical findings and other tests.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Nuclear Pore Protein IgG Blot
Frequently asked questions
This test is primarily used in specialized clinical or research settings to support the diagnosis of autoimmune diseases involving nuclear pore proteins, such as lupus or other rare connective tissue disorders. It may help confirm suspected autoimmune activity or guide treatment decisions in specific patient populations.
A positive result indicates the presence of IgG antibodies against nuclear pore proteins, which may suggest an autoimmune response. However, this alone does not confirm a diagnosis. Your healthcare provider will interpret results in the context of your symptoms, medical history, and other tests.
While this test may be part of a broader evaluation for autoimmune conditions like lupus, it is not a definitive diagnostic tool. Doctors rely on clinical findings, other lab tests, and patient symptoms to make a diagnosis.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy