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NUDT15 Gene Mutation Analysis (Carrier Status)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a specific variation in the NUDT15 gene, which may influence how your body processes certain medications.

Quick summary

["Knowing your NUDT15 gene status can help doctors tailor your treatment for conditions like certain cancers or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100665-9
Short code
NUDT15 gene c.415C>T Bld Ql
Synonyms
NUDT15 gene c.415C>T Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

NUDT15 is an enzyme involved in drug metabolism. Certain genetic variations in this gene can affect how efficiently your body breaks down medications. This test identifies whether you carry the common NUDT15 variant (rs7124196) that may impact drug response.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you’re taking medications that rely on NUDT15 activity, such as certain chemotherapy drugs or antibiotics, or if you have a family history of conditions influenced by genetic variations in this gene.

Sample Collection and Process

A small amount of blood is drawn from your arm to collect DNA for testing. The test analyzes your genetic material to determine if you carry the NUDT15 variant.

What the Results Mean

Results typically show whether you are a carrier of the NUDT15 variant. This information helps guide treatment decisions, especially for medications that may require dose adjustments based on genetic factors.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

While NUDT15 variants are common and usually harmless, they can influence how certain drugs are processed in your body. For example, some chemotherapy drugs may work differently in people with this variant, potentially affecting effectiveness or side effects. Your doctor will use this information to personalize your treatment plan.

Short name

NUDT15 Gene Test

Frequently asked questions

Will this test affect my medication?
Possibly. Some medications may need to be adjusted if you carry the NUDT15 variant, but this depends on the specific drug and your overall health. Always discuss any changes with your doctor.
How long does it take to get results?
Results are usually available within 1 to 2 weeks after the blood sample is collected.
Is this test covered by insurance?
Coverage depends on your insurance plan and medical reason for testing. Check with your provider or insurance company to confirm coverage details.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy