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NUDT15 Gene Mutation Analysis (Carrier Status)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a specific variation (mutation) in the NUDT15 gene, which may influence how your body processes certain medications or metabolic pathways.

Quick summary

["This test helps assess genetic predisposition to certain drug responses or metabolic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100666-7
Short code
NUDT15 gene c.416G>A Bld Ql
Synonyms
NUDT15 gene c.416G>A Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The NUDT15 gene mutation is analyzed to determine if it is present in your DNA. This test specifically looks for a particular variant (mutation) in the NUDT15 gene, which can affect how your body metabolizes drugs like methotrexate or other medications.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you are taking medications that rely on NUDT15 activity, such as certain chemotherapy drugs, or if you have a family history of conditions linked to genetic variations in this gene.

Sample Collection and Process

A blood sample is typically collected to analyze your genetic material. This test involves extracting DNA from your blood cells and sequencing the NUDT15 gene to identify the mutation.

What the Results Mean

Results are qualitative (positive or negative) for the presence of the NUDT15 mutation. A positive result means you carry this genetic variation, which may require adjustments to your medication dose or treatment plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Genetic Testing for NUDT15 Mutation

Short name

NUDT15 Gene Test

Frequently asked questions

NUDT15 gene mutations can influence how your body processes certain medications, potentially affecting their effectiveness or safety. For example, certain chemotherapy drugs may require dose adjustments if you carry this mutation to prevent toxicity or reduce effectiveness.
This test is primarily used to guide personalized treatment plans, especially for patients on medications that rely on NUDT15 activity for metabolism.
How does this test differ from other genetic tests?
Unlike many genetic tests that assess multiple genes or conditions, this test focuses specifically on the NUDT15 gene mutation. It is tailored to evaluate how this single genetic variation may impact drug metabolism in your body.
What if my test result is positive for the NUDT15 mutation?
If your result is positive, your healthcare provider may recommend closer monitoring of your medication levels or adjustments to your treatment plan to ensure safety and effectiveness.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy