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NUDT15 Gene Mutation Analysis (Deletion in Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for a specific genetic deletion in the NUDT15 gene, which may affect how your body processes certain medications or contribute to rare genetic conditions.

Quick summary

A genetic test to identify a deletion in the NUDT15 gene that could influence medication response or health risks.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100669-1
Short code
NUDT15 gene c.50_55del Bld Ql
Synonyms
NUDT15 gene c.50_55del Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of genetic conditions, are considering certain medications that interact with the NUDT15 gene, or if symptoms suggest a genetic basis for your health concerns.

What the Test Measures

This test detects a deletion in the NUDT15 gene, which is part of your DNA. The deletion may alter how your body processes drugs like methotrexate, a medication sometimes used for autoimmune diseases or cancer.

Sample Collection

A small amount of your blood will be drawn from a vein in your arm. This is a standard procedure and is typically done in a lab setting.

What to Expect Before the Test

No special preparation is needed, but you may want to avoid eating or drinking for a short time before the blood draw if instructed by your provider.

Frequently asked questions

What does a positive result mean?
A positive result means the deletion in the NUDT15 gene was found in your blood sample. This may influence how your healthcare provider manages medications or monitors your health, especially if you are taking drugs processed by this gene.
Will this test affect my treatment plan?
Possibly. If you are on medications like methotrexate, your doctor may adjust your dose or monitoring based on the test results to ensure safe and effective treatment.
Is this test covered by insurance?
Coverage depends on your insurance plan and medical necessity. Check with your insurance provider or healthcare team to confirm if this test is covered for your specific situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy