NUDT15 Gene Mutation Analysis (Duplex, Carrier Status)
This test checks whether you carry a specific genetic variation in the NUDT15 gene, which may influence how your body processes certain medications.
["Knowing your carrier status for NUDT15 can help your healthcare provider tailor your medication treatment more precisely."]
Key facts at a glance
- LOINC
- 100664-2
- Short code
- NUDT15 gene c.50_55dup&c.415C>T Bld Ql
- Synonyms
- NUDT15 gene c.50_55dup&c.415C>T Bld Ql
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The NUDT15 gene mutation can affect how your liver metabolizes medications like clopidogrel (a blood thinner). This test identifies whether you carry one copy of the altered gene, which may require adjustments in your medication plan.
Why It Matters in Medicine
Carrying the NUDT15 variant can lead to lower levels of active clopidogrel in your blood, potentially reducing its effectiveness in preventing blood clots. This test helps doctors determine if you need a different medication or dosage.
What to Expect Before the Test
No special preparation is needed for this genetic test. A small blood sample will be taken from your arm, similar to a regular blood draw. Results are typically available within a few weeks.
What the Results Mean
Results will indicate whether you carry the NUDT15 gene variant. If you do, your healthcare provider may recommend alternative medications or closer monitoring of your blood clotting levels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The NUDT15 gene variant is clinically relevant primarily for patients prescribed clopidogrel or similar medications. It helps identify individuals who may not respond effectively to these drugs, allowing for safer and more effective treatment planning. This genetic screening is not routinely recommended for all patients but may be offered based on risk factors or specific medical needs.
Short name
NUDT15 Gene Carrier Test
Frequently asked questions
Will this test affect my insurance coverage?
How long will I need to wait for my results?
Can I get this test if I don’t take clopidogrel?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy