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NUDT15 Gene Mutation Analysis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for mutations in the NUDT15 gene, which may influence how your body processes certain medications, including chemotherapy drugs.

Quick summary

["Understanding your NUDT15 gene status can help doctors tailor your treatment plan more precisely."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100667-5
Short code
NUDT15 gene c.52G>A Bld Ql
Synonyms
NUDT15 gene c.52G>A Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’re receiving chemotherapy that relies on the enzyme NUDT15 for metabolism. Certain mutations in this gene can affect how well your body breaks down these drugs, potentially altering their effectiveness or side effects.

What to Expect Before the Test

No special preparation is needed for this genetic test. A small blood sample will be taken from your arm, similar to a regular blood draw. Results are typically available within 1–2 weeks.

What the Results Mean

Results will identify whether you have mutations in the NUDT15 gene. These findings can help doctors adjust your chemotherapy dose or choose alternative treatments to optimize safety and effectiveness.

Common Side Effects or Considerations

While this test itself doesn’t cause side effects, the medications influenced by NUDT15 may have known risks (e.g., nausea, fatigue, or blood-related issues). Discuss these with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: NUDT15 Gene and Chemotherapy

Short name

NUDT15 Gene Test

Frequently asked questions

What questions should I ask my doctor about this test?
Ask about the specific chemotherapy drugs you’re taking and how NUDT15 mutations might affect them. Also inquire about follow-up testing or alternative treatment options if results suggest a genetic influence.
Will this test affect my insurance coverage?
Genetic testing may be covered by insurance if ordered as part of a clinical decision for your treatment. Check with your provider and insurance company to confirm coverage details.
How long will I need to wait for results?
Results typically take 1–2 weeks, but timing may vary. Your doctor will contact you once they’re ready to discuss the findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy