Skip to content

NUDT15 Gene Mutation Analysis (Whole Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic variations in the NUDT15 gene, which may affect how your body processes certain medications.

Quick summary

["Knowing your NUDT15 gene status can help doctors choose safer or more effective treatments for conditions like chemotherapy or blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93194-9
Short code
NUDT15 gene Mut Anl Bld/T
Synonyms
NUDT15 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The NUDT15 gene mutation test identifies specific changes (mutations) in the NUDT15 gene found in your blood cells. These mutations can influence how enzymes work in your body, potentially altering how medications are broken down.

Why It’s Done

Doctors may order this test if you’re about to start a medication that relies on the NUDT15 enzyme pathway, such as certain chemotherapy drugs or blood thinners. It helps prevent side effects or reduce the risk of treatment failure.

Sample Collection and Preparation

A small blood sample is taken from your arm, similar to a regular blood draw. The sample is processed to isolate DNA from your white blood cells for genetic analysis.

What to Expect Before the Test

No special preparation is needed, but inform your doctor about any medications you’re taking, as some may affect test results or treatment planning.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Mutations in the NUDT15 gene can lead to reduced enzyme activity, which may require adjustments to your medication dose. For example, some patients with these mutations may need lower doses of certain chemotherapy drugs to avoid toxicity. Genetic testing helps tailor treatment to your unique biology.

Short name

NUDT15 Mutation Test

Frequently asked questions

Will this test affect my treatment plan?
Possibly. If you have a NUDT15 mutation, your doctor may adjust your medication dose, choose a different drug, or monitor you more closely to ensure safety and effectiveness.
How long will it take to get results?
Results are typically available within 1–2 weeks after the blood sample is collected. Your doctor will discuss the findings with you.
Can I eat or drink before this test?
You can eat and drink normally before the test, as no special preparation is required. However, always follow your doctor’s specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy