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Alpha-1 Antitrypsin (A1AT) Serum Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["A1AT levels help assess lung and liver health, especially in conditions like chronic obstructive pulmonary disease (COPD) or genetic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56334-6
Short code
Oat Poln IgG4-mCnc
Synonyms
Oat Poln IgG4-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Alpha-1 Antitrypsin is crucial for maintaining lung and liver function. Low levels may indicate genetic disorders (like Alpha-1 Antitrypsin Deficiency) or chronic lung diseases. This test helps doctors diagnose and monitor these conditions early.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on blood thinners, let your doctor know before the test.

How the Results Are Used

Your results help determine if you have a genetic disorder or lung disease. High levels may suggest liver problems, while low levels often point to lung damage or inherited conditions.

Common Conditions Linked to A1AT Levels

Low A1AT levels are most commonly linked to Alpha-1 Antitrypsin Deficiency, which can cause lung diseases (like emphysema) or liver cirrhosis. High levels may rarely indicate liver disease or inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What does my A1AT level mean if it’s lower than expected?
A lower-than-normal A1AT level may suggest Alpha-1 Antitrypsin Deficiency, a genetic condition that increases your risk of lung diseases like emphysema or chronic bronchitis. If your doctor suspects this, they may recommend genetic testing or lung function evaluations.
Could my A1AT level be affected by medications or health conditions?
Certain medications (like some antibiotics or steroids) or liver diseases can temporarily affect A1AT levels. If you’re on long-term medications or have liver issues, discuss this with your doctor—they may adjust your test interpretation.
Why would my doctor order this test?
Your doctor may order this test if you have symptoms of lung disease (like chronic coughing or shortness of breath), a family history of Alpha-1 Antitrypsin Deficiency, or if you’ve been diagnosed with liver disease. It helps identify whether your symptoms are related to low A1AT levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy