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Ovarian Cancer Screening Antigen (OvCA) Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific proteins in your blood that may help detect ovarian cancer early. It’s part of a broader assessment for gynecologic health.

Quick summary

["Early detection of ovarian cancer may improve treatment outcomes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
83690-8
Short code
OBGYN Attend Note
Synonyms
OBGYN Attend Note
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
obstetrics-and-gynecology-attending
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The OvCA Profile typically includes markers like CA-125 (a tumor-associated glycoprotein) and other ovarian cancer-specific antigens. These proteins can be elevated in ovarian cancer but may also appear in other conditions, so results are interpreted in context with clinical findings.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like bloating, pelvic pain, or changes in bowel habits. It’s also used in follow-up for women at higher risk (e.g., due to family history or genetic mutations).

How the Test Works

A blood sample is drawn, and the lab analyzes protein levels using immunoassay techniques (e.g., enzyme-linked immunosorbent assay). Results are compared to reference ranges for the specific markers.

What the Results Mean

Elevated levels of certain markers may signal ovarian cancer or other gynecologic conditions, but they’re not definitive. Your provider will discuss findings with you, considering symptoms, medical history, and imaging results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

OvCA Profile

Frequently asked questions

What does a positive or elevated result mean?
A positive result may indicate ovarian cancer or another condition affecting ovarian tissue. Further diagnostic testing, like imaging or biopsy, will be needed to confirm or rule out cancer.
Can this test detect ovarian cancer in early stages?
While it can help identify potential issues, no single test is 100% accurate for early-stage detection. It’s part of a broader evaluation, often used alongside clinical judgment and imaging.
Does this test require fasting?
No fasting is required, but follow your provider’s instructions for timing your blood draw.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy