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Ovarian Cancer Screening: Serum Tumor Marker (CA-125) with Electrophoresis Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures specific proteins in your blood that may be elevated in ovarian cancer or other gynecologic conditions. It helps healthcare providers assess risk, monitor treatment, or detect early signs of disease.

Quick summary

["Elevated levels may signal ovarian cancer or other gynecologic concerns; results guide further testing or care."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
78721-8
Short code
OBGYN Discharge teach note
Synonyms
OBGYN Discharge teach note
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
obstetrics-and-gynecology
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test includes a detailed electrophoresis profile of CA-125 (Cancer Antigen 125), a glycoprotein often produced by ovarian cancer cells. Electrophoresis separates proteins by size and charge, allowing for qualitative assessment of CA-125 distribution patterns. This can help identify abnormal protein fragments linked to ovarian cancer or other conditions.

Why It’s Done

Your doctor may order this test if you have symptoms like bloating, pelvic pain, or unexplained weight changes; if you’re at higher risk (e.g., family history); or as part of routine monitoring after treatment for ovarian cancer or other gynecologic cancers.

How It’s Performed

A blood sample is drawn, and the serum is analyzed using electrophoresis to detect and profile CA-125 levels. This method helps identify abnormal protein patterns that may indicate underlying health concerns.

What to Expect

You’ll receive your results from your healthcare provider, who will explain whether the test was normal or if additional testing is needed. CA-125 alone is not a definitive diagnostic tool but can support decision-making with other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CA-125 Profile

Frequently asked questions

What does a ‘profile’ mean in this test?
A profile refers to the electrophoresis breakdown of CA-125, showing how the protein separates into different fractions. This can reveal patterns that may correlate with ovarian cancer or other conditions, helping healthcare providers assess risk more precisely.
Can I fast before this test?
No fasting is required for this blood test. However, always follow your doctor’s instructions for any other related tests or preparations.
Is this test covered by insurance?
Coverage depends on your insurance plan and clinical indication. Check with your provider or insurance company to confirm if this screening is approved for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy