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Ovarian Cancer Screening Biomarker Profile (Note)

Published: August 9, 2026Updated: August 16, 2026

This test measures certain substances in your blood that may help detect or monitor ovarian cancer. It’s often used alongside other tests to assess risk or response to treatment.

Quick summary

["Early detection and monitoring of ovarian cancer may be supported by these biomarkers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
83558-7
Short code
OBGYN NP Note
Synonyms
OBGYN NP Note
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
obstetrics-and-gynecology-nurse-practitioner
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test includes a panel of biomarkers that may be elevated in ovarian cancer or related conditions. These substances can help identify abnormal cell activity in the ovaries or surrounding tissues. The exact biomarkers included may vary by lab protocol, but they often include substances like CA-125 (Cancer Antigen 125) and other tumor markers.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like persistent bloating, pelvic pain, or unexplained weight changes. It may also be used in screening for high-risk individuals or during follow-up for ovarian cancer patients.

How the Test Works

A blood sample is drawn, and the lab analyzes it for specific biomarkers. These biomarkers are detected using sensitive immunoassay methods, which identify and measure the presence of substances in your blood.

Preparation for the Test

No special preparation is needed for this test. You can eat, drink, and take medications as usual on the day of your appointment. Avoiding alcohol or strenuous activity for 24 hours before the test may help ensure accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Ovarian Cancer Biomarker Check

Frequently asked questions

Ovarian cancer often doesn’t produce symptoms until it’s advanced. Biomarkers like CA-125 can signal potential cancer activity, but they are not definitive on their own. They are typically used alongside imaging and other tests for a complete evaluation.
This test may not detect all ovarian cancers, especially early-stage ones. False positives or negatives can occur, so results should be interpreted by a healthcare provider in the context of your medical history and symptoms.
What Are the Most Common Biomarkers Included?
The exact biomarkers depend on the lab’s protocol, but common ones may include CA-125, HE4 (Human Epididymalis Protein 4), and other tumor markers. These are not the only substances measured; the test may also include other substances related to ovarian health.
How Often Should This Test Be Done?
Frequency depends on your medical history, risk factors, and healthcare provider’s recommendations. High-risk individuals (e.g., those with a family history of ovarian cancer) may be screened more regularly, while others may have it done less often or as needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy