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24-Hour Urinary Sodium and Chloride Concentration Profile

Published: August 9, 2026Updated: August 17, 2026

This test measures how much sodium and chloride appear in your urine over 24 hours, helping assess kidney function and fluid balance.

Quick summary

["Helps diagnose kidney issues and electrolyte imbalances by tracking urine salt levels over a full day."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
31108-4
Short code
OF .40% NaCl 24h Inc NFr RBC
Synonyms
OF .40% NaCl 24h Inc NFr RBC
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test plays an important role in protecting your health because it gives your care team reliable information about how your body is functioning. The results can help confirm or rule out a condition, guide treatment decisions, and detect potential problems early, when they are often easiest to treat and manage.

Your kidneys filter waste and balance electrolytes like sodium and chloride. This test checks if your kidneys are working properly by tracking how much of these salts appear in your urine over a full day. Abnormal results may signal conditions like kidney disease, fluid retention, or hormonal imbalances.

Before the test, your provider will explain the procedure and give you clear instructions to follow. Depending on the type of test, you may be asked to fast for a set number of hours, avoid certain foods, drinks, or medications, or drink extra water. Be sure to tell your care team about all medications you take, any allergies you have, and whether you have ever had a reaction to a similar test.

You’ll collect all urine for 24 hours, starting after midnight of one day and ending after midnight the next. Store samples in a refrigerator and bring the full collection to your lab visit. Avoid certain medications (e.g., diuretics) that could affect results without discussing them with your provider first.

During the test, a trained member of your care team will carry out a simple, routine procedure designed to measure specific values in your body. Depending on the test, this may involve collecting a small sample or taking specialized readings. The sample or measurements are then analyzed, and your provider will receive the results to review with you and explain what they mean for your health.

Your urine is tested for sodium and chloride concentrations using a specialized method that measures the amount of these salts in your urine. Results are compared to typical values to identify any imbalances.

This type of testing is commonly used to monitor conditions such as diabetes, high cholesterol, thyroid disorders, anemia, and kidney or liver disease. Regular monitoring allows your provider to see how a condition is changing over time, evaluate how well your current treatment is working, and adjust your care plan as needed to help you stay as healthy as possible.

This test helps diagnose or monitor conditions like chronic kidney disease, hypertension, or conditions affecting fluid balance, such as heart failure or certain hormonal disorders.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Interpretation of Results

Short name

24h Urine Na/Cl Profile

Frequently asked questions

How much sodium and chloride are in your urine over 24 hours can reveal kidney function, fluid retention, or electrolyte imbalances. For example, high levels may indicate kidney problems or excessive salt intake, while low levels could signal dehydration or kidney dysfunction.
Yes, some preparation is often helpful. Your provider may ask you to fast for a certain number of hours, hold certain medications or supplements, or avoid alcohol before the test. Always follow the specific instructions your care team gives you, and call the office ahead of time if anything is unclear.
Yes, you’ll need to collect all urine for a full 24-hour period. Follow your provider’s instructions carefully to ensure accurate results. Avoid certain medications that might affect sodium/chloride levels unless approved by your doctor.
A normal result generally means that the values measured fall within the expected range, which can be reassuring about your current health. However, it does not always rule out every possible problem, so your provider will interpret the result alongside your symptoms, medical history, and any other tests you have had.
A normal result suggests your kidneys are filtering sodium and chloride appropriately and your fluid balance is stable. However, your provider will interpret results in relation to your overall health and medical history.
No, you’ll need to follow specific fluid intake guidelines provided by your healthcare team to ensure accurate results. Drinking too much or too little could affect the sodium/chloride measurements.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy