24-Hour Urinary Sodium and Chloride Concentration Profile
This test measures how much sodium and chloride appear in your urine over 24 hours, helping assess kidney function and fluid balance.
["Helps diagnose kidney issues and electrolyte imbalances by tracking urine salt levels over a full day."]
Key facts at a glance
- LOINC
- 31108-4
- Short code
- OF .40% NaCl 24h Inc NFr RBC
- Synonyms
- OF .40% NaCl 24h Inc NFr RBC
- Category
- electrolyte
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 4.2
- Ref high
- 5.9
- Critical range
- 2 N/A – 7 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85041
- SNOMED
- 900000000000003001
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
This test plays an important role in protecting your health because it gives your care team reliable information about how your body is functioning. The results can help confirm or rule out a condition, guide treatment decisions, and detect potential problems early, when they are often easiest to treat and manage.
Your kidneys filter waste and balance electrolytes like sodium and chloride. This test checks if your kidneys are working properly by tracking how much of these salts appear in your urine over a full day. Abnormal results may signal conditions like kidney disease, fluid retention, or hormonal imbalances.
Before the test, your provider will explain the procedure and give you clear instructions to follow. Depending on the type of test, you may be asked to fast for a set number of hours, avoid certain foods, drinks, or medications, or drink extra water. Be sure to tell your care team about all medications you take, any allergies you have, and whether you have ever had a reaction to a similar test.
You’ll collect all urine for 24 hours, starting after midnight of one day and ending after midnight the next. Store samples in a refrigerator and bring the full collection to your lab visit. Avoid certain medications (e.g., diuretics) that could affect results without discussing them with your provider first.
During the test, a trained member of your care team will carry out a simple, routine procedure designed to measure specific values in your body. Depending on the test, this may involve collecting a small sample or taking specialized readings. The sample or measurements are then analyzed, and your provider will receive the results to review with you and explain what they mean for your health.
Your urine is tested for sodium and chloride concentrations using a specialized method that measures the amount of these salts in your urine. Results are compared to typical values to identify any imbalances.
This type of testing is commonly used to monitor conditions such as diabetes, high cholesterol, thyroid disorders, anemia, and kidney or liver disease. Regular monitoring allows your provider to see how a condition is changing over time, evaluate how well your current treatment is working, and adjust your care plan as needed to help you stay as healthy as possible.
This test helps diagnose or monitor conditions like chronic kidney disease, hypertension, or conditions affecting fluid balance, such as heart failure or certain hormonal disorders.
Reference range
Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Interpretation of Results
Short name
24h Urine Na/Cl Profile
Frequently asked questions
How much sodium and chloride are in your urine over 24 hours can reveal kidney function, fluid retention, or electrolyte imbalances. For example, high levels may indicate kidney problems or excessive salt intake, while low levels could signal dehydration or kidney dysfunction.
Yes, you’ll need to collect all urine for a full 24-hour period. Follow your provider’s instructions carefully to ensure accurate results. Avoid certain medications that might affect sodium/chloride levels unless approved by your doctor.
A normal result suggests your kidneys are filtering sodium and chloride appropriately and your fluid balance is stable. However, your provider will interpret results in relation to your overall health and medical history.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy