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Serum or plasma total protein concentration (mass concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the total amount of protein in your blood serum or plasma, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
50794-7
Short code
OF start NFr RBC
Synonyms
OF start NFr RBC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, malnutrition, or certain infections. It can also help evaluate fluid balance or diagnose conditions like edema or protein-losing syndromes.

What to Expect

A small blood sample is drawn from your arm. The blood is processed to separate serum or plasma, and the protein concentration is measured using a specialized lab technique. Results are typically ready within a few days.

Normal vs. Abnormal Results

While reference ranges vary by lab, higher than expected levels may suggest dehydration, multiple myeloma, or severe liver disease. Lower levels could indicate malnutrition, kidney disease, or liver dysfunction. Your results will be interpreted by your provider in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor liver function, kidney health, and protein synthesis. It may also be part of routine checks for patients with chronic illnesses like heart failure or autoimmune disorders.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What causes my total protein test result to be different from what’s expected?
Several factors can influence your results, including diet (high-protein foods), hydration status, certain medications, or underlying health conditions like liver or kidney disease. If you suspect an issue, discuss your results with your provider and share any recent changes in diet, medications, or symptoms.
How soon will I know my results, and what should I do next?
Results are usually available within a few days, but timing depends on your lab. Your provider will explain the meaning of your results and next steps, such as additional tests or lifestyle adjustments. Follow their guidance closely.
Can I prepare for this test in any special way?
No special preparation is needed, but avoid heavy meals or excessive alcohol before the test. If you’re on blood thinners or have a history of bleeding disorders, let your provider know to ensure safe blood drawing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy