2-Hydroxydecanedioate/Creatinine Ratio, Urine
A urine test that measures 2-hydroxydecanedioate relative to creatinine. It may help evaluate suspected disorders of peroxisomal metabolism.
["This specialized urine test can help investigate rare inherited disorders that affect how the body processes fatty acids."]
Key facts at a glance
- LOINC
- 13761-2
- Short code
- OH-Decanedioate/Creat Ur
- Synonyms
- OH-Decanedioate/Creat Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures 2-hydroxydecanedioate, a substance that can be increased in certain rare inherited conditions, in urine. The result is compared with the urine creatinine level to help account for differences in urine concentration.
Why might I need this test?
A clinician may order this test as part of an evaluation for a suspected peroxisomal disorder, particularly when an infant or child has unusual symptoms, developmental concerns, or findings that suggest a metabolic problem. It is usually interpreted by a metabolic or genetics specialist.
How is the test performed?
A urine specimen is collected and analyzed in a laboratory. The laboratory measures 2-hydroxydecanedioate and creatinine and reports their ratio; the specific analytical method may vary by laboratory.
How do I prepare for the test?
Follow the collection instructions provided by your clinician or laboratory, which may request a first-morning or timed urine sample. Tell the healthcare team about any medicines, supplements, diet changes, or recent illness, because these can sometimes affect urine testing.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated ratio may be seen in disorders that impair peroxisome function, including Zellweger spectrum and related peroxisomal biogenesis disorders. The result is not diagnostic by itself and must be interpreted with symptoms, other laboratory findings, and possibly genetic testing by a specialist.
Short name
Urine 2-hydroxydecanedioate-to-creatinine ratio
Frequently asked questions
Is this the same as a routine urinalysis?
Why is the result divided by creatinine?
Does an abnormal result confirm a genetic disorder?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy