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Hydroxydecanedioate/Creatinine [Mass Ratio] in Urine

Published: August 9, 2026Updated: August 16, 2026

Measures urinary hydroxydecanedioate relative to creatinine, which helps account for differences in urine concentration.

Quick summary

["This urine test measures a metabolic marker and is best interpreted with your other laboratory results and symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25108-2
Short code
OH-Decanedioate/Creat Ur-sRto
Synonyms
OH-Decanedioate/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures hydroxydecanedioate, a metabolite, in urine and compares its amount with the urine creatinine level. The ratio helps account for how concentrated or dilute a urine sample is.

Why might I need this test?

This test may be used to evaluate unusual results on a newborn screening panel or to investigate a suspected inborn error of metabolism. It is usually interpreted with symptoms, physical findings, and other laboratory tests.

How is the test performed?

A urine sample is collected and analyzed in the laboratory to determine the hydroxydecanedioate-to-creatinine ratio. The result is reported as a calculated ratio rather than as a standalone urine concentration.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. Special preparation is not usually required, but the laboratory may specify a timed or first-morning collection depending on why the test is being done.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine hydroxydecanedioate-to-creatinine ratio

Frequently asked questions

Does an abnormal result mean I have a metabolic disorder?
No. An abnormal result can occur for several reasons and does not establish a diagnosis by itself. Your clinician will consider your symptoms, screening results, and other laboratory tests.
Why is creatinine included in this test?
Creatinine is used to adjust the hydroxydecanedioate measurement for urine concentration. This makes results more comparable between samples and across age groups.
Is this the same as a standard newborn screening test?
It may be used as a follow-up or supplementary test after an abnormal screening result. It does not replace the initial newborn screening panel.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy