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Proline in Serum (or Plasma) – Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of the amino acid proline in your blood, which helps assess protein metabolism and certain liver or kidney conditions.

Quick summary

["Proline levels may indicate how well your body processes proteins or if organs like your liver or kidneys are functioning properly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27181-7
Short code
OH-Proline Amn-sCnc
Synonyms
OH-Proline Amn-sCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like fatigue, muscle weakness, or signs of liver disease (such as jaundice). It can also be part of monitoring for conditions like liver cirrhosis, kidney disease, or metabolic disorders.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The sample is then sent to a lab where proline levels are measured using a specialized analytical method.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours if your test includes additional bloodwork. Avoid strenuous activity the day before.

What Are Common Causes of Abnormal Results?

Elevated proline levels may suggest liver disease, kidney failure, or certain metabolic disorders. Lower levels might indicate malnutrition, severe dehydration, or conditions affecting protein synthesis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Proline Level

Frequently asked questions

What does a proline test tell your doctor?
This test is less commonly used alone but may be part of a broader evaluation for liver or kidney function, protein metabolism issues, or monitoring chronic conditions. Your doctor will interpret results in the context of your overall health and symptoms.
How soon will I get my results?
Results are typically available within 1 to 3 business days, depending on your lab. Your healthcare provider will discuss them with you during your follow-up visit.
Can I eat or drink before this test?
Most often, no special diet is required, but always follow your healthcare provider’s instructions. If fasting is required, avoid food and liquids (except water) for the specified period before your test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy