Oligoclonal Band IgG Profile (24-Hour Urine Collection)
This test measures the presence of specific antibodies (IgG proteins) that form distinct bands when analyzed by electrophoresis. These bands may indicate an immune response, often linked to conditions like multiple sclerosis or other neurological disorders.
["This test helps identify unusual antibody patterns that could signal underlying health concerns."]
Key facts at a glance
- LOINC
- 58800-4
- Short code
- Oligoclonal Bands 24h Ur IEF-Imp
- Synonyms
- Oligoclonal Bands 24h Ur IEF-Imp
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- isoelectric-focusing
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Is the Purpose of This Test?
Doctors may order this test to investigate symptoms like unexplained fatigue, numbness, or weakness, especially if you have a history of neurological conditions. It can also help diagnose or monitor conditions affecting the immune system or central nervous system.
How Is the Sample Collected?
You’ll collect a 24-hour urine sample in a sterile container, typically starting and ending at the same time each day. The sample must be kept refrigerated and returned to the lab within a specified timeframe to ensure accuracy.
What Does the Test Measure?
The test analyzes the urine for specific IgG antibodies that form distinct bands when separated by electrophoresis. These bands represent clusters of antibodies that may not be present in normal urine samples.
What Are Common Reasons for This Test?
Common reasons include evaluating multiple sclerosis, neuromyelitis optica, or other autoimmune or inflammatory neurological conditions. It may also be used in research or to assess immune responses in certain diseases.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test can help identify abnormal immune activity in the central nervous system. Elevated or distinct IgG bands may suggest conditions like multiple sclerosis, where the immune system attacks the protective covering of nerves. However, results alone cannot diagnose a condition; they are usually interpreted alongside clinical findings and other tests.
Short name
IgG Oligoclonal Bands (Urine)
Frequently asked questions
Why was I asked to provide a 24-hour urine sample?
What does it mean if my test shows oligoclonal bands?
Can I take medications before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy