Oligoclonal Band IgG Profile by Serum Protein Electrophoresis
This test measures the presence of multiple small bands of immunoglobulin G (IgG) proteins in your blood, which may indicate an immune response to certain conditions.
["IgG oligoclonal bands can help diagnose conditions affecting the nervous system or immune system."]
Key facts at a glance
- LOINC
- 56765-1
- Short code
- Oligoclonal Bands IgM CSF Ql IEF
- Synonyms
- Oligoclonal Bands IgM CSF Ql IEF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- isoelectric-focusing
- CPT
- 82784
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your doctor may order this test if you have symptoms like unexplained fatigue, numbness, weakness, or neurological issues that could suggest conditions such as multiple sclerosis, Guillain-Barré syndrome, or other autoimmune or inflammatory diseases. It helps identify unusual patterns of antibodies in your bloodstream.
How Is the Sample Collected?
A small amount of blood is drawn from a vein in your arm by a healthcare professional. The blood is then sent to a lab for analysis.
What Does the Test Show?
The test uses serum protein electrophoresis to separate different proteins in your blood. IgG oligoclonal bands appear as distinct bands on the electrophoresis result, which may indicate an abnormal immune response. These bands are not typically seen in healthy individuals.
What Are the Possible Results?
If IgG oligoclonal bands are present, they may suggest conditions like multiple sclerosis, certain infections, or autoimmune diseases. However, they can also appear in people without symptoms. Your doctor will interpret the results in the context of your medical history and other test results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: IgG oligoclonal bands are often associated with demyelinating diseases such as multiple sclerosis, where the immune system attacks the protective covering of nerves. They can also appear in other conditions like viral infections, autoimmune disorders, or certain cancers. While they can be a marker for these conditions, they are not definitive on their own and should be evaluated alongside clinical findings.
Short name
IgG Oligoclonal Bands
Frequently asked questions
What does an abnormal result mean?
How soon will I get my results?
Can I do anything to prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy