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Total Protein in Serum or Plasma (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess liver function, nutritional status, and potential kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99376-6
Short code
Olive Poln IgG-mCnc
Synonyms
Olive Poln IgG-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your doctor may order this test to check for conditions like liver disease, kidney problems, malnutrition, or dehydration. It can also help monitor protein-losing disorders or track responses to treatments.

What to Expect

A small blood sample is taken from a vein, usually in your arm. The blood is sent to a lab where it’s analyzed for protein content. Results are typically ready within a few days.

Normal vs. Abnormal Results

While reference ranges vary by lab, higher than expected levels might suggest dehydration or conditions like multiple myeloma. Lower levels could indicate liver disease, kidney problems, or malnutrition.

Common Conditions Linked to Results

Elevated protein levels may signal dehydration, severe infections, or certain cancers. Low protein levels can point to liver or kidney disease, poor nutrition, or conditions like nephrotic syndrome.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

How long does it take to get my total protein test results?
Results are usually available within 1–3 business days, depending on your lab. Your healthcare provider will discuss them with you during your follow-up visit.
Can I eat or drink anything before this test?
No special preparation is needed for this test. You can eat and drink normally, but avoid alcohol for 24 hours before your blood draw if advised by your doctor.
What if my protein levels are out of range?
If your results are abnormal, your doctor may recommend further tests (like albumin or liver/kidney function tests) or adjustments to your diet, medications, or treatment plan.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy