Skip to content

Serum Creatinine Phosphokinase (CPK) Isoenzyme Assay (Total CPK)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total activity of Creatine Phosphokinase (CPK), an enzyme found in heart, muscle, and brain tissues. It helps assess muscle damage, heart function, or neurological conditions.

Quick summary

["CPK levels can indicate damage to muscles, heart, or nerves."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108992-9
Short code
OmpC IgA Msmt Ser
Synonyms
OmpC IgA Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Creatine Phosphokinase (CPK)?

Creatine Phosphokinase (CPK), also called creatine kinase, is an enzyme that helps produce energy in cells. It exists in three forms (CPK-MB, CPK-MM, CPK-BB), with the total CPK combining all three. High levels often signal tissue damage, such as in heart attacks, muscle injuries, or neurological disorders.

Why Might You Need This Test?

Your doctor may order this test to diagnose or monitor conditions like heart attacks (myocardial infarction), muscle injuries, stroke, or other conditions affecting muscle or nerve function. It’s also used in some cases of seizures or other neurological issues.

When Is This Test Performed?

This test is typically done when symptoms suggest muscle or heart damage, such as chest pain, muscle weakness, or unexplained fatigue. Blood is drawn from a vein, usually in a lab setting.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to avoid strenuous exercise or certain medications that could affect results. If you’re on blood thinners, let your doctor know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total CPK

Frequently asked questions

How long does it take to get results?
Results are usually available within 24 to 48 hours, depending on the lab. Your doctor will discuss them with you during your follow-up.
Can CPK levels be affected by diet or exercise?
Yes, intense exercise or certain foods (like high-protein meals) can temporarily raise CPK levels. However, chronic elevations may indicate underlying conditions requiring medical evaluation.
What if my CPK levels are high?
High CPK levels may signal muscle damage, heart issues, or neurological problems. Your doctor will review your symptoms and other test results to determine the cause and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy