Oncologic Chromosomal Analysis by Sequencing (SMP-Seq)
This test examines genetic changes in cancer cells using advanced sequencing to identify mutations, gene rearrangements, or other alterations that may influence treatment decisions.
["Helps tailor cancer care by uncovering genetic details unique to your tumor."]
Key facts at a glance
- LOINC
- 94590-7
- Short code
- Oncologic chrom analy Tiss MPSeq
- Synonyms
- Oncologic chrom analy Tiss MPSeq
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- mate-pair-sequencing
- CPT
- 86038
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
SMP-Seq (Single-Molecule Processed Sequencing) analyzes DNA from your tumor sample to detect specific genetic alterations, including single nucleotide variants, insertions/deletions, and structural rearrangements. It focuses on regions commonly altered in oncology, such as oncogenes or tumor suppressor genes, to identify potential targets for targeted therapies or guide surgical planning.
How the Sample Is Collected
Your healthcare provider will take a small biopsy of your tumor during surgery or another procedure. The sample is then processed in the lab to extract DNA for sequencing. This is not a routine blood or urine test but is performed specifically for cancer-related genetic analysis.
Preparation and Process
No special preparation is needed before the biopsy. After collection, the lab isolates tumor DNA and sequences it to detect genetic variations. Results are reviewed by medical professionals to interpret clinical significance.
When This Test Might Be Ordered
Your doctor may recommend this test if you have a known or suspected cancer, especially if treatment options include targeted therapies (e.g., immunotherapy, kinase inhibitors). It’s also used in research settings or for precision oncology programs.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
This test provides critical insights into your cancer’s genetic makeup, helping doctors choose the most effective treatment. Genetic alterations may indicate whether a tumor responds to specific drugs, guide decisions about surgery, or inform prognosis. It’s particularly useful for cancers with known genetic drivers (e.g., lung, breast, colorectal) where targeted therapies exist.
A positive result identifies genetic changes in your tumor that may explain its behavior or growth patterns. These findings can direct treatment choices, such as recommending a specific drug or surgical approach. However, results alone don’t determine cure—your doctor will integrate them with other clinical factors.
Results typically take 2–4 weeks from sample collection, depending on lab workflow and complexity. Your healthcare team will contact you once available, and they’ll explain findings in the context of your diagnosis and treatment plan.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy