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Opioid (specifically tramadol) mass concentration in plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of tramadol, a prescription pain medication, in your blood plasma. It helps assess drug levels to ensure safe dosing and monitor for potential toxicity.

Quick summary

["Knowing your tramadol level helps doctors adjust your dose for pain relief without risking overdose."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105952-6
Short code
O-nortramadol Ur-mCnc
Synonyms
O-nortramadol Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking tramadol for chronic or acute pain, if you’ve had side effects like dizziness, confusion, or slow breathing, or if you’re adjusting your dose. It can also be used to confirm compliance with prescribed medication or evaluate drug interactions.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or vein for blood collection. The process takes a few minutes, and you may feel a brief pinch. If you’re on blood thinners, let your provider know before testing.

What the Results Mean

Results are typically reported in micrograms per milliliter (µg/mL) or nanograms per milliliter (ng/mL). While reference ranges vary by lab, very high levels may indicate overdose or improper metabolism, while very low levels might suggest insufficient pain control.

Possible Side Effects or Risks

The most common side effects of tramadol include drowsiness, nausea, or dizziness. Rarely, very high blood levels can cause severe side effects like respiratory depression or seizures. Your provider will discuss risks based on your medical history and current medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Tramadol Plasma Level

Frequently asked questions

How often should I get this test?
Your provider will determine the frequency based on your treatment plan, pain management goals, and medical history. For example, they may recommend testing after dose adjustments or if you experience unusual symptoms.
Can I drink alcohol while taking tramadol?
No, alcohol can increase tramadol’s effects, leading to drowsiness, confusion, or respiratory issues. Always follow your provider’s instructions and avoid mixing medications with alcohol.
What if my results are outside the normal range?
If your tramadol level is too high, your provider may adjust your dose, prescribe a different medication, or monitor you more closely. If it’s too low, they may increase your dose or check for other factors affecting absorption.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy