Gastric Microbial Community Profile (16S rRNA Gene Sequencing)

Why It’s Done

Your healthcare provider may recommend this test if you have symptoms like persistent stomach discomfort, unexplained weight changes, or conditions linked to altered gut microbiota, such as gastroparesis or certain digestive disorders. It can also be part of research or monitoring for conditions like inflammatory bowel disease or food intolerances.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for a few hours before the procedure. Your sample will be collected via a simple swab of your stomach lining, often done during an endoscopy or with an oral rinse. Avoid eating or drinking for a specified period beforehand to ensure accurate results.

What the Results Mean

Results show the relative abundance of different bacterial species in your stomach. A healthy microbiome usually contains a diverse mix of bacteria, while imbalances (dysbiosis) may indicate infections, inflammation, or other underlying issues. Your provider will interpret these findings in the context of your symptoms and medical history.

Common Conditions Monitored

This test helps diagnose or monitor conditions such as Helicobacter pylori infection (a common stomach bacteria linked to ulcers or gastritis), chronic gastritis, or other gastrointestinal disorders. It may also be used in research settings to study gut health or evaluate the effects of treatments like antibiotics or probiotics.