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Serum or plasma total protein concentration (qualitative screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the overall amount of protein in your blood serum or plasma, which includes both albumin and globulin proteins. It helps assess overall protein status and potential issues like malnutrition, kidney disease, or liver problems.

Quick summary

["A qualitative screening helps identify abnormal protein levels that may require further testing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18495-2
Short code
O+P sp3 Stl Tri Stn
Synonyms
O+P sp3 Stl Tri Stn
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
trichrome-stain
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, or severe malnutrition. It can also be part of routine health evaluations or when symptoms like swelling, fatigue, or unexplained weight loss appear.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw, where a small amount of blood is taken from a vein in your arm. If a urine sample is used, you might be asked to collect a midstream sample at home. Always follow your provider’s instructions for any fasting or fluid restrictions.

What Happens During the Test?

Blood or urine is sent to a lab for analysis. The test is qualitative, meaning it provides a yes/no or high/low result rather than a precise number. Results are typically reviewed within hours or days, depending on lab processes.

What Are Possible Results?

Results may be categorized as normal, low, or high. Low protein levels could suggest conditions like malnutrition, kidney disease, or liver failure. High levels might indicate dehydration, multiple myeloma, or severe inflammation. Your provider will discuss these findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal serious health concerns. Low protein levels may indicate poor nutrient absorption, chronic diseases, or excessive protein loss (e.g., from kidney disease). High protein levels could reflect dehydration, certain cancers, or immune system disorders. Early detection helps guide treatment plans.

Short name

Total Protein (Qualitative Screen)

Frequently asked questions

What Does a Low Total Protein Level Mean?
A low result may suggest conditions like malnutrition, liver disease, or kidney problems. Your provider will likely order additional tests to determine the cause and recommend appropriate care, such as dietary changes or medical treatments.
What Does a High Total Protein Level Mean?
High protein levels might indicate dehydration, multiple myeloma, or severe infections. Further testing may be needed to identify the underlying cause, such as blood tests or imaging studies to address potential conditions like cancer or immune disorders.
Can Diet Affect This Test?
Yes, diet can influence protein levels. High-protein diets or certain medical conditions may temporarily alter results. If you have dietary restrictions or concerns, discuss them with your provider before the test to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy