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Total Serum IgE (Immunoglobulin E) Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that plays a role in allergic reactions and responses to parasites.

Quick summary

["IgE levels can help identify allergies or immune system conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61248-1
Short code
Orange IgE/IgE total %
Synonyms
Orange IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Immunoglobulin E (IgE)?

IgE is a protein produced by your immune system in response to allergens (substances like pollen, dust, or certain foods) or parasitic infections. While IgE is normal in small amounts, elevated levels may signal allergies, asthma, or other immune-related conditions.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like sneezing, itching, rashes, or breathing difficulties. It can also help diagnose conditions like allergic rhinitis, eczema, or certain parasitic infections.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab, where it is analyzed to measure IgE levels using an immunoassay method.

What Do Results Mean?

Results are typically reported in units of IgE per milliliter (IU/mL). Higher than normal levels may indicate allergies or immune disorders, while lower levels may suggest a weakened immune response to certain allergens.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated IgE Levels

Short name

IgE Total

Frequently asked questions

How often do IgE levels change over time?
IgE levels can fluctuate depending on allergens you’re exposed to, underlying health conditions, or medications you take. Your doctor may retest if symptoms persist or worsen.
Can IgE levels be affected by diet?
Diet alone typically doesn’t drastically alter IgE levels, but certain foods (like nuts, dairy, or shellfish) may trigger allergic reactions in people with elevated IgE.
What if my IgE levels are very high?
Very high IgE levels may require further testing or evaluation by an allergist to determine the cause, such as allergies, asthma, or immune system disorders. Treatment may include allergy shots, medications, or avoiding known triggers.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy