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Organic Acids Profile in Blood (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific organic acids in your blood over a 24-hour period, often used to diagnose metabolic disorders like mitochondrial diseases or inborn errors of metabolism.

Quick summary

["Helps identify rare genetic conditions affecting how your body processes nutrients and energy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17386-4
Short code
Organic Acids Bld-aCnc
Synonyms
Organic Acids Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like unexplained muscle weakness, fatigue, developmental delays, or neurological issues. It’s particularly useful for diagnosing conditions where organic acids build up in the body, which can interfere with normal cell function.

What to Expect Before the Test

You’ll need to collect a 24-hour urine sample starting after breakfast on the first day. Follow your doctor’s instructions carefully to ensure accurate results, as missing any urine or not collecting it properly can affect the test.

How the Test Works

Your urine is analyzed using advanced laboratory techniques, such as high-performance liquid chromatography (HPLC), to measure levels of various organic acids. These acids are small molecules produced during normal metabolism that can sometimes become elevated in certain genetic disorders.

What the Results Mean

Elevated levels of specific organic acids may indicate an underlying metabolic disorder. Your doctor will interpret the results in the context of your symptoms, medical history, and other tests to guide diagnosis and treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Organic Acids Profile

Frequently asked questions

What causes abnormal organic acid levels?
Abnormal levels may be due to genetic mutations that impair how your body breaks down certain nutrients. Conditions like mitochondrial disorders, inborn errors of metabolism, or certain medications can also contribute.
How is this test different from other metabolic tests?
Unlike some tests that measure single analytes (like lactate or ammonia), this profile evaluates multiple organic acids simultaneously, providing a broader picture of metabolic function.
Can lifestyle changes affect this test?
Yes, diet and fluid intake can influence urine collection. Avoid certain foods (e.g., high-protein or high-sugar diets) and follow your doctor’s instructions to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy