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Organic Acids, Creatinine, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures organic acids and may adjust the result for urine concentration using creatinine, helping evaluate the body's metabolism.

Quick summary

["This test can help identify metabolic problems, but results must be interpreted with symptoms, diet, medications, and other laboratory findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14295-0
Short code
Organic Acids/Creat Ur-sRto
Synonyms
Organic Acids/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures organic acids in urine. These substances are produced during normal metabolism, and the laboratory may use the urine creatinine level to help account for how concentrated the urine sample is.

Why might I need this test?

It may be ordered when symptoms suggest an inherited metabolic disorder, especially in children with unexplained growth problems, developmental concerns, seizures, muscle weakness, vomiting, or episodes of altered mental status. It may also help assess nutrition or possible effects of medications.

How is the test performed?

You provide a urine sample according to the laboratory's instructions. The laboratory analyzes the sample for organic acids and may determine the creatinine concentration at the same time.

How do I prepare for the test?

Follow any collection instructions from your healthcare professional or laboratory. Some testing centers request a first-morning or fasting sample, and prompt delivery may be important, so tell the laboratory if you recently changed medications, supplements, or diet.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results can occur with an inherited disorder of amino acid, fatty acid, or organic acid metabolism. Elevated levels may also reflect recent illness, fasting, unusual dietary intake, or certain medications, so an abnormal result alone does not establish a diagnosis.

Short name

Urine Organic Acids

Frequently asked questions

Does this test diagnose a metabolic disorder by itself?
No. Results are interpreted with symptoms, medical history, other laboratory tests, and sometimes genetic testing to determine whether a metabolic disorder is likely.
Why is creatinine included in the test?
Urine concentration can vary from sample to sample. Comparing the organic acid result with creatinine can help make the measurement more representative.
Can diet or medications affect the results?
Yes. Fasting, recent illness, diet, supplements, and medications may influence urine organic acid levels. Tell your healthcare professional about these factors before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy