Organic Acid Profile (Urinary)

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like frequent vomiting, muscle weakness, or unusual smells in your urine. It’s also used in diagnosing metabolic disorders such as mitochondrial diseases, organic acidemias, or other inherited metabolic conditions.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain foods or medications for a few days before the test. Drink plenty of water to help flush out acids naturally. Avoid taking vitamin supplements or certain medications that could interfere with results.

How the Test Is Performed

A urine sample is collected, often through a simple midstream or timed collection (e.g., 24-hour urine). The sample is then analyzed using advanced laboratory techniques, such as gas chromatography or mass spectrometry, to identify and measure specific organic acids.

What the Results Mean

Abnormal results may indicate an imbalance in how your body processes certain acids, which could signal metabolic disorders. Elevated or missing acids may point to specific conditions that require further medical evaluation, including genetic testing.