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Organic Acid Profile (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures levels of certain organic acids in your blood or plasma, which can help identify metabolic disorders or other health conditions.

Quick summary

["Helps diagnose metabolic issues by checking for abnormal acid buildup."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35866-3
Short code
Organic Acids Pnl SerPl
Synonyms
Organic Acids Pnl SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unusual smells on your breath, vomiting, weakness, or if you have a family history of metabolic disorders. It may also be used to monitor certain genetic conditions or metabolic diseases.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the blood draw. Bring any medications you’re currently taking to your appointment.

What the Test Involves

A small needle will be used to draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood sample will be sent to a lab for analysis.

What the Results Mean

Abnormal levels of specific organic acids can indicate metabolic disorders, such as mitochondrial diseases, inborn errors of metabolism, or other conditions affecting how your body processes nutrients. Your provider will discuss the results with you in detail.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Organic Acids

Frequently asked questions

What causes abnormal organic acid levels?
Abnormal results may be due to genetic mutations, certain medications, infections, or metabolic disorders. If you have symptoms like fatigue, unusual smells, or unexplained weight changes, discuss them with your provider.
How often should I get this test?
Your provider will determine the frequency based on your health needs, symptoms, or if you have a known metabolic condition. Regular monitoring may be needed if you have a diagnosed disorder.
Can diet affect this test?
Dietary changes may influence certain organic acids, so follow any fasting instructions provided by your lab. Avoid excessive alcohol or certain supplements that could interfere with results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy