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Orotate/Creatinine Ratio, Urine — Turbidimetry

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures orotic acid relative to creatinine, helping evaluate abnormal orotic acid metabolism and urinary excretion.

Quick summary

["This test measures how much orotic acid is excreted in urine relative to creatinine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110363-9
Short code
Orotate/Creat Msmt Ur
Synonyms
Orotate/Creat Msmt Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Orotate is a natural compound formed during metabolism. This urine test measures orotic acid relative to creatinine, a substance used to help account for differences in urine concentration.

Why might I need this test?

A clinician may order this test when there is concern about an inherited disorder of pyrimidine metabolism, such as hereditary orotic aciduria, or when unexplained orotic acid elevations need further evaluation.

How is the test performed?

A urine specimen is analyzed using a turbidimetric laboratory method. The amount of orotic acid is compared with the amount of creatinine in the same sample to provide a ratio.

How do I prepare for the test?

Follow the collection instructions provided by your clinician or laboratory, including whether a first-morning or timed urine sample is required. The laboratory will explain any restrictions, and special diet or medication changes should occur only if your clinician directs them.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated urine orotate-to-creatinine ratio may reflect increased production or reduced elimination of orotic acid and can occur with inherited metabolic disorders. Results may also be affected by transient metabolic changes, so an abnormal result usually requires clinical interpretation and sometimes additional testing.

Short name

Urine orotate/creatinine ratio

Frequently asked questions

Does this test diagnose hereditary orotic aciduria?
It can support evaluation for the condition, but an elevated result alone is not diagnostic. Genetic testing, other urine tests, and clinical findings may be needed.
Why is the result reported as a ratio?
Creatinine helps account for how concentrated or dilute the urine sample is. The ratio makes results easier to compare across urine samples.
Can diet or medications affect the result?
Recent illness, nutritional changes, and some medications can influence orotic acid excretion. Tell your clinician about medications, supplements, and relevant medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy