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Urine Orotate-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

Measures urine orotate relative to creatinine, helping assess orotic acid production while accounting for urine concentration.

Quick summary

["This urine test can help evaluate suspected disorders of pyrimidine metabolism, particularly in children."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13787-7
Short code
Orotate/Creat Ur
Synonyms
Orotate/Creat Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of orotate in urine compared with the amount of creatinine. Creatinine is used to account for how concentrated or dilute the urine sample is.

Why might I need this test?

The test may be used to investigate suspected inborn errors of pyrimidine metabolism, including hereditary orotic aciduria. It may also be considered when a child has unexplained developmental, growth, or blood-cell abnormalities.

How is the test performed?

A urine sample is analyzed for orotate and creatinine, and the results are used to calculate their ratio. The laboratory may measure a single urine sample or collect urine over a specified period, depending on the test protocol.

How do I prepare for the test?

Follow the laboratory's instructions for urine collection. If a 24-hour collection is requested, record all urine produced during that period and store it as directed. Ask the laboratory whether any medication or dietary restrictions apply.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Orotate/Creatinine Ratio

Frequently asked questions

What does an elevated result mean?
It may suggest a disorder affecting pyrimidine metabolism, including hereditary orotic aciduria. Other findings are needed to confirm the cause.
Why is the result divided by creatinine?
Urine creatinine helps show how concentrated the sample is. The ratio makes it easier to compare orotate levels across samples with different urine concentrations.
Is this the same as a routine urine creatinine test?
No. A routine creatinine test measures creatinine alone, while this test calculates the relative amount of orotate to creatinine in the urine sample.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy