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Orotate-to-Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that compares orotate with creatinine, helping account for differences in urine concentration.

Quick summary

["This test measures orotate relative to creatinine in urine and may help evaluate suspected metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32262-8
Short code
Orotate/Creat Ur-Rto
Synonyms
Orotate/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures orotate, a compound involved in nucleotide production, in urine and compares it with urine creatinine. The ratio helps reduce the effect of variations in urine concentration.

Why might I need this test?

It may be used to help evaluate unusual orotic acid production, including a rare inherited condition called hereditary orotic aciduria. It is sometimes used alongside other laboratory and genetic tests rather than by itself.

How is the test performed?

A urine sample is collected and analyzed in the laboratory. The laboratory reports the amount of orotate relative to the amount of creatinine in the same sample.

How do I prepare for the test?

Follow any instructions provided by your healthcare professional. Collection timing and diet may affect the result, so tell the laboratory if the test was ordered for a newborn, child, or pregnant patient, and discuss whether medications or supplements should be paused.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Orotate/Creatinine Ratio

Frequently asked questions

What does the urine orotate-to-creatinine ratio measure?
It compares the amount of orotate with the amount of creatinine in urine. Creatinine serves as a reference for urine concentration.
Is this the same as a routine urine creatinine test?
No. A routine urine creatinine test may measure creatinine alone, while this test reports the calculated relationship between orotate and creatinine.
What if my result is abnormal?
An abnormal result does not establish a specific diagnosis by itself. Your healthcare professional may review symptoms, medical history, medications, and additional metabolic or genetic tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy