Orthopoxvirus IgG Immunoglobulin G Antibody Test (Serum/Plasma)
This test measures the level of antibodies (IgG) your body produces in response to exposure to orthopoxviruses, a group of viruses that includes smallpox and vaccinia (the virus used in the smallpox vaccine).
["This test helps assess past exposure to orthopoxviruses, which may be important for monitoring vaccination status or evaluating exposure risks."]
Key facts at a glance
- LOINC
- 100893-7
- Short code
- Orthopoxvirus IgG + IgM Ab panel SerPl
- Synonyms
- Orthopoxvirus IgG + IgM Ab panel SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test detects IgG antibodies specific to orthopoxviruses. IgG antibodies are a type of immune protein your body creates after being exposed to a virus, either through infection or vaccination. These antibodies remain in your blood for a longer period than other immune responses, helping your body remember the virus for future protection.
Why Might You Need This Test?
Your healthcare provider may order this test if you have a history of orthopoxvirus exposure (such as from vaccination or occupational risk), if you’ve had symptoms suggestive of an orthopoxvirus infection, or as part of monitoring for conditions related to these viruses.
What Does a Positive Result Mean?
A positive result indicates that your body has produced IgG antibodies against orthopoxviruses, suggesting past exposure—whether from infection or vaccination. This does not confirm a current active infection but confirms your immune system has recognized the virus.
What Does a Negative Result Mean?
A negative result means your body did not detect IgG antibodies specific to orthopoxviruses at the time of testing. This could mean you have never been exposed or vaccinated, or your immune response may not have developed detectable antibodies yet.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used for surveillance, research, or occupational health purposes. For example, it may be used to confirm vaccination status in individuals at risk of exposure (e.g., healthcare workers handling orthopoxvirus samples) or to study immune responses in outbreaks. It is not typically used for diagnosing active orthopoxvirus infections, as symptoms and other diagnostic tests would usually be prioritized first.
Short name
Orthopoxvirus IgG
Frequently asked questions
How is this test different from an orthopoxvirus PCR test?
Can this test be used to confirm a recent vaccination?
How long does it take to get results from this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy