Cerebrospinal Fluid White Blood Cell Count (Manual Differential)

Why This Test Is Done

Your doctor may order this test if you have symptoms like headaches, neck stiffness, fever, confusion, or neurological problems that suggest an infection, inflammation, or other condition affecting the central nervous system. It can also be part of routine monitoring for certain conditions.

What to Expect Before the Test

No special preparation is needed. You may be asked to lie down on your side with your head slightly raised, and a needle will be inserted into your back to collect a small amount of CSF. The procedure is usually quick and painless.

What Happens During the Test

A healthcare provider will insert a needle into your lower back to collect CSF. The fluid is then examined under a microscope to count and identify different types of white blood cells. The manual differential process involves carefully classifying each cell type.

What the Results Mean

The results will show the total white blood cell count and the proportion of different cell types (e.g., lymphocytes, neutrophils). Elevated counts may indicate infection, inflammation, or other neurological conditions, while normal results suggest no immediate concern.