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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Blood proteins help maintain fluid balance and support immune function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18328-5
Short code
Other Stn Fld
Synonyms
Other Stn Fld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xxx-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your doctor may order this test to check for conditions like kidney disease, liver problems, or malnutrition, where protein levels might be affected. It can also help monitor treatment responses or detect fluid imbalances.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein (usually in your arm) to draw blood. If you’re nervous, let your healthcare provider know—some people find it helpful to bring distractions or talk through the process.

Common Conditions Monitored

Low protein levels might suggest conditions like severe kidney disease, malnutrition, or liver failure. High levels could indicate dehydration, inflammation, or certain blood disorders.

What the Results Mean

Results are compared to a general reference range based on age, sex, and health. Your doctor will interpret your specific results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Levels and Health

Short name

Total Protein

Frequently asked questions

How often will I need this test?
Your doctor will determine how often you need this test based on your health condition and treatment plan. Some people get it once a year, while others may need it more frequently if they have ongoing health issues.
What if my results are outside the normal range?
If your results are outside the normal range, your doctor may recommend further tests or changes to your treatment plan. They’ll discuss this with you and explain what it means for your health.
Can diet affect my protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein may help maintain stable results. If you have dietary restrictions or concerns, talk to your doctor or dietitian before your test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy