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Total Protein Mass Concentration (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["Your blood protein levels help assess overall health and identify potential issues like malnutrition or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97968-2
Short code
Ovalb IgG4-mCnc
Synonyms
Ovalb IgG4-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Doctors may order a total protein test to check for conditions like malnutrition, kidney disease, liver problems, or certain immune disorders. It can also help monitor treatment progress for conditions affecting protein levels.

What to Expect

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed for protein content. Results are typically ready within a few days.

Normal vs. Abnormal Results

While exact reference ranges vary by lab, higher-than-normal protein levels might suggest conditions like multiple myeloma or severe dehydration. Lower-than-normal levels could indicate malnutrition, liver disease, or kidney problems.

Common Conditions Affecting Results

Changes in total protein can signal underlying health issues. For example, low protein may point to poor nutrient absorption, while high protein could indicate chronic inflammation or disease processes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels are a broad marker and often used alongside other tests to diagnose specific conditions. They don’t provide detailed information about individual protein types (like albumin or globulins).

Short name

Total Protein

Frequently asked questions

What causes my protein levels to be different from what’s considered normal?
Several factors can influence protein levels, including diet, kidney or liver function, chronic illnesses, or medications. If your results are outside the expected range, discuss them with your doctor to explore possible causes.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other tests. Routine checks may be recommended if you have conditions like kidney disease or liver issues.
Can I prepare for this test in any special way?
No special preparation is needed for this blood test. However, avoid eating or drinking anything (except water) for a few hours before your appointment if instructed by your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy