Red Blood Cell (RBC) Morphology Evaluation – Ovalocyte Count

What Are Ovalocytes?

Ovalocytes are red blood cells that have a more rounded, oval shape instead of the typical biconcave disc shape. While most red blood cells are smooth and flat, ovalocytes can appear slightly larger or irregular. This variation can sometimes be a normal variant in certain populations or may signal an underlying health concern.

Why Might Your Doctor Order This Test?

Your doctor may check for ovalocytes if you have symptoms like fatigue, pale skin, or signs of anemia, or if they suspect conditions such as hereditary elliptocytosis, thalassemia, or other blood disorders. This test is often part of a broader red blood cell evaluation.

How Is This Test Performed?

Ovalocyte count is typically performed as part of a complete blood count (CBC) or a detailed red blood cell morphology examination. A small sample of your blood is examined under a microscope by a trained laboratory professional to identify and count ovalocytes among other red blood cells.

What Does an Ovalocyte Count Tell You?

An elevated ovalocyte count may suggest conditions that affect red blood cell shape, such as genetic disorders or conditions that damage red blood cells prematurely. A normal count does not rule out all causes of ovalocytes, so your doctor will consider other factors, including symptoms and lab results.