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Oxycodone concentration in serum/plasma (drug screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain reliever, in your blood. It helps doctors assess drug exposure, monitor treatment, or investigate suspected overdose.

Quick summary

["This test helps track opioid levels for medical or legal reasons."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73221-4
Short code
oxyCODONE+ASA ind plt IgG SerPl Ql FC
Synonyms
oxyCODONE+ASA ind plt IgG SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re taking oxycodone for pain management, if you’ve been exposed to opioids, or if there’s suspicion of misuse, overdose, or drug-related issues. It can also be part of routine monitoring in certain clinical settings.

What to Expect Before the Test

No special preparation is needed unless instructed by your doctor. You may be asked to fast before the draw, but this isn’t always required. Bring a list of all medications you’re taking to avoid false results.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm. The blood sample is sent to a lab for analysis using a high-performance liquid chromatography (HPLC) method to detect oxycodone and related compounds.

What Does the Test Result Mean?

Results are typically reported as a concentration in micrograms per milliliter (µg/mL). Higher levels may indicate recent use, overdose risk, or improper dosing. Your doctor will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Oxycodone Level (Serum/Plasma)

Frequently asked questions

How long does it take to get the results?
Test results are usually available within 1–3 business days, depending on lab processing times. Follow-up with your doctor to discuss findings.
Can I drink alcohol before this test?
Alcohol itself won’t affect this test, but it may influence your overall health or opioid metabolism. Avoid excessive alcohol use before testing if your doctor advises it.
Is this test covered by insurance?
Check with your insurance provider to confirm coverage, as results may vary. Some labs or providers may charge out-of-pocket costs for this screening.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy