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Oxycodone concentration in plasma (quantitative drug screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain medication, in your blood plasma. It helps assess your current drug levels, monitor adherence to treatment, or detect recent use.

Quick summary

["This test helps doctors track opioid levels for pain management or to check for misuse."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73220-6
Short code
oxyCODONE+ASA ind plt IgM SerPl Ql FC
Synonyms
oxyCODONE+ASA ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking oxycodone regularly, experiencing side effects, or if there’s concern about potential drug interactions or misuse. It can also be used to verify compliance with prescribed doses or to evaluate how your body processes the medication.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a small needle inserted into your arm or vein to draw a blood sample. If you’re concerned about needles, let your healthcare provider know in advance.

How the Test Results Are Used

Results help your doctor determine if your dose is appropriate, if you’re absorbing the medication correctly, or if you may need adjustments. Very high levels could indicate misuse or overdose, while very low levels might suggest poor absorption or non-compliance.

Possible Side Effects or Considerations

Oxycodone is a controlled substance, so test results may be used for legal or treatment-related purposes. If you’re pregnant, breastfeeding, or have liver/kidney issues, discuss these with your doctor before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Oxycodone Plasma Level

Frequently asked questions

What does a high oxycodone level mean?
A high level may suggest recent misuse, improper dosing, or potential overdose. Your doctor will review the result alongside your medical history and symptoms to guide next steps, such as adjusting your medication or seeking further evaluation.
What does a low oxycodone level mean?
A low level might indicate poor absorption of the medication, non-compliance with dosing, or liver/kidney issues affecting drug metabolism. Your doctor will consider this in combination with your symptoms and medical history to determine the best course of action.
Can this test detect other drugs?
This test specifically measures oxycodone. If you’re concerned about other substances in your system, your doctor may order additional screening tests, such as a broader drug panel.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy