Skip to content

Oxycodone Concentration (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain medication, in your blood. It helps assess drug levels to guide treatment or evaluate toxicity.

Quick summary

["Knowing your oxycodone levels helps doctors monitor safety and effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4370-3
Short code
oxyCODONE Dose
Synonyms
oxyCODONE Dose
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re taking oxycodone long-term, if you’ve experienced side effects like drowsiness, confusion, or slowed breathing, or if you’re suspected of drug overdose. It can also help adjust your dose if needed.

What to Expect Before the Test

No special preparation is usually needed. You’ll provide a blood sample, typically drawn from a vein in your arm. If you’re on blood thinners, let your doctor know before the test.

How the Test Works

Blood is collected and sent to a lab where it’s analyzed using a sensitive detection method to measure oxycodone concentration. Results are reported in micrograms per milliliter (µg/mL).

What the Results Mean

Results help determine whether your dose is appropriate for your needs and safety. High levels may indicate overdose or improper metabolism, while low levels could suggest insufficient medication.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Oxycodone Level

Frequently asked questions

What does a high oxycodone level mean?
A high level may suggest overdose, improper dosing, or issues with how your body processes the drug. Your doctor will review the result with you and may adjust your treatment plan.
Can food or other medications affect oxycodone levels?
Yes, certain foods, other medications, or even alcohol can change how oxycodone works in your body. Always tell your doctor about all medications or supplements you take.
How often will I need this test?
Frequency depends on your treatment plan. Your doctor may order it regularly if you’re on long-term opioid therapy or if you’ve had concerns about drug levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy