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Oxycodone (Serum/Plasma Concentration) - Quantitative Drug Screening

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription pain medication, in your blood. It helps assess your current drug level and whether you’re taking the medication as prescribed.

Quick summary

["Knowing your oxycodone level helps ensure safe dosing and monitor potential risks of misuse or overdose."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46256-4
Short code
oxyCODONE Free SerPl Ql Scn
Synonyms
oxyCODONE Free SerPl Ql Scn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
screen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re prescribed oxycodone, experiencing pain, or suspected of drug misuse. It can also be used to verify compliance with treatment plans or evaluate side effects.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on a blood thinner, let your provider know before the test.

What the Results Mean

Results show your current oxycodone concentration in your blood. Higher levels may indicate recent use, while lower levels could suggest recent elimination or non-compliance. Your provider will interpret these results in the context of your medical history and symptoms.

Common Reasons for Testing

This test helps track how your body processes oxycodone, adjusts doses for effectiveness, or detects potential issues like overdose, addiction, or improper mixing with other substances.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Oxycodone Level

Frequently asked questions

How long does it take to get my test results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Follow-up with your provider to discuss findings.
Can I drink water before this test?
Yes, you can drink water, but avoid caffeine or alcohol for at least 1 hour before your blood draw to avoid potential test interference.
Will this test show if I’ve used oxycodone illegally?
This test specifically measures oxycodone in your bloodstream, not illegal use. For broader drug screening (including illicit substances), a separate urine or hair test may be needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy