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Oxycodone concentration in plasma or serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain medication, in your blood. It helps determine your current drug level and whether you’re taking it as prescribed.

Quick summary

["This test helps assess your opioid exposure and potential risks of overdose or dependence."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68543-8
Short code
oxyCODONE Mec Cfm-mCnt
Synonyms
oxyCODONE Mec Cfm-mCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re taking oxycodone regularly, experiencing symptoms like confusion, slow breathing, or unusual drowsiness, or if you’ve been exposed to oxycodone in another way (e.g., accidental ingestion). It can also be used to monitor compliance with treatment or detect misuse.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The sample is then sent to a lab to measure the oxycodone concentration using a sensitive detection method, often a type of immunoassay or chromatography.

What Should You Expect Before the Test?

No special preparation is usually needed, but avoid eating or drinking anything for at least 8 hours before the test if instructed. If you’re taking other medications, let your provider know to avoid potential interactions.

What Are Common Results?

Results are reported as the concentration of oxycodone in nanograms per milliliter (ng/mL) or micrograms per milliliter (µg/mL). These values can vary based on factors like dosage, metabolism, and time since last dose. Your provider will interpret the results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Oxycodone Level (Plasma/Serum)

Frequently asked questions

What Does a High Level Mean?
High levels may indicate improper use, overdose risk, or recent ingestion of oxycodone. This can lead to serious side effects like slowed breathing, drowsiness, or even coma. Your provider will assess your symptoms and overall health to determine next steps.
What Does a Low Level Mean?
Low levels may suggest insufficient dosing, rapid metabolism, or recent discontinuation of the medication. If you’re experiencing pain or other symptoms, your provider might adjust your treatment plan.
How Often Should This Test Be Done?
The frequency depends on your medical needs. For chronic pain management, tests may be done periodically to monitor drug levels and adjust doses safely. If you’re in a supervised setting (e.g., detox program), tests might be more frequent.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy