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Oxycodone concentration in urine (24-hour collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain medication, in your urine over a 24-hour period. It helps assess recent exposure or misuse.

Quick summary

["This test checks for recent opioid use, often used in pain management or substance abuse evaluations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26869-8
Short code
oxyCODONE Mec-mCnt
Synonyms
oxyCODONE Mec-mCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking oxycodone for pain relief, if you’re suspected of opioid misuse, or as part of a broader evaluation for substance use. It can also be used to monitor compliance with prescribed medication or screen for potential drug interactions.

What to Expect Before the Test

No special preparation is needed. Collect your urine in a sterile container over a full 24-hour period, starting and ending with your first and last voids of the day. Bring the sample to your lab with the collection dates marked.

How the Test Works

Your urine sample is analyzed using a sensitive laboratory method to detect and quantify oxycodone. The test measures the drug’s presence in your system, reflecting recent ingestion.

What the Results Mean

Results are reported in micrograms per milliliter (µg/mL) for the 24-hour urine sample. A positive result indicates detectable levels of oxycodone, but interpretation depends on clinical context (e.g., prescribed use vs. suspected misuse).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Oxycodone (24h)

Frequently asked questions

What does a high or low result indicate?
A positive result suggests recent oxycodone exposure, which may be due to prescribed use, accidental ingestion, or misuse. If you’re prescribed oxycodone, elevated levels could indicate improper dosing or non-compliance. If you’re suspected of substance misuse, this test helps assess patterns of use. Always discuss results with your healthcare provider.
How often should I get this test?
The frequency depends on your medical needs. If you’re prescribed oxycodone, your doctor may order this test periodically to monitor your response to treatment or for safety. If you’re part of a substance use evaluation, follow your provider’s instructions for follow-up testing.
Can I drink alcohol before this test?
Alcohol does not interfere with this urine test, but it’s important to follow your provider’s instructions for other medications or substances that might affect your health during your evaluation. Avoid alcohol if you’re concerned about its impact on your treatment or overall well-being.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy