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Oxycodone concentration in urine (24-hour collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of oxycodone, a prescription opioid pain medication, in your urine over a 24-hour period. It helps assess recent exposure or misuse.

Quick summary

["This test checks for recent opioid use in your urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73996-1
Short code
oxyCODONE Mec Ql Scn
Synonyms
oxyCODONE Mec Ql Scn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
screen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test helps your doctor find out whether a certain condition may be present in your body. The results provide important information that guides decisions about your diagnosis and your treatment plan going forward.

Your healthcare provider may order this test if you have concerns about opioid use, are undergoing treatment for pain management, or are part of a drug screening program. It can also be used in workplace or legal settings to detect recent opioid exposure.

The test measures specific markers in the sample collected from you. When these markers appear at certain levels, they show how your body is functioning and help your care team confirm or rule out the condition being checked.

Oxycodone is collected in a 24-hour urine specimen. The sample is analyzed using a sensitive laboratory method to detect and quantify the drug. This method ensures accurate measurement of oxycodone levels, even at low concentrations.

A trained member of our staff will collect your sample using a simple, safe procedure. The collection usually takes only a few minutes, and you can go home right afterward and return to your normal daily routine.

You will be provided with a clean container and instructions to collect all urine produced in a 24-hour period, typically from one morning to the next morning. It’s important to follow these instructions precisely to ensure accurate results.

Before the test, your care team will explain each step and answer any questions you have. You may be given simple instructions, such as fasting for a period of time or pausing certain medicines, so follow them closely to help ensure your results are accurate.

No special preparation is needed, but you may be asked to avoid certain medications or substances that could interfere with the test results. If you are pregnant, breastfeeding, or have allergies, let your healthcare provider know.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Urine Oxycodone (24h)

Frequently asked questions

A positive result indicates recent use of oxycodone, which may suggest misuse, addiction, or compliance with treatment. High levels could also indicate improper use or contamination. Low or absent levels may mean no recent exposure or adherence to prescribed use.
A positive result means the test detected the marker it was looking for, which suggests the condition may be present. Your doctor will review the result with you, explain what it means in your situation, and discuss any follow-up testing or treatment that may be needed.
A positive result means your urine contained detectable amounts of oxycodone within the past 24 hours. This could be due to prescribed use, misuse, or exposure to the drug. Your healthcare provider will discuss the next steps based on your situation, such as adjusting treatment plans or addressing concerns about substance use.
Yes, some foods, drinks, and medications can affect your results, which is why we give you preparation instructions ahead of time. Tell your care team about every medication and supplement you take, and follow any fasting or restriction guidelines they provide.
While diet generally does not affect urine drug tests, certain medications or substances (like some supplements) may interfere with the test. If you are unsure, ask your healthcare provider to confirm if any medications or substances could impact your results.
Typically, you should wait at least 24 hours after your last dose of oxycodone to retest, as the drug may still be detectable in your urine. However, follow your healthcare provider’s specific instructions, as timing can vary depending on individual metabolism and other factors.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy