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Oxycodone and Oxymorphone Concentration in Saliva

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of oxycodone and oxymorphone, two opioid pain medications, in your saliva. It helps assess recent drug use.

Quick summary

["Detects recent opioid exposure through saliva samples."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71430-3
Short code
oxyCODONE+oxyMORphone Sal Ql Scn
Synonyms
oxyCODONE+oxyMORphone Sal Ql Scn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
screen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have concerns about recent opioid use, are suspected of opioid misuse, or are undergoing treatment for pain management or addiction. Saliva testing is often used for quick, non-invasive monitoring of recent drug exposure.

What to Expect Before the Test

No special preparation is needed. You’ll provide a saliva sample, typically collected by swabbing your inner cheek. Avoid eating, drinking, chewing gum, or smoking for at least 30 minutes before testing to ensure accurate results.

What the Test Results Mean

Positive results indicate recent opioid use, but they don’t confirm long-term dependence or abuse. Results are used to guide treatment decisions, monitor compliance with medication regimens, or screen for substance use disorders.

Possible Results and Next Steps

If results are positive, your provider may discuss further testing (e.g., blood or urine), treatment options, or referrals to addiction support services. Negative results mean no detectable opioids were found in your saliva at the time of testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Drug Screen (Saliva)

Frequently asked questions

What does a positive result mean?
A positive result means opioids (oxycodone or oxymorphone) were detected in your saliva within the last few hours. This suggests recent ingestion, but it doesn’t indicate long-term use or addiction alone. Your provider will interpret results in the context of your medical history and symptoms.
Can I eat or drink before this test?
Yes, but avoid eating, drinking, chewing gum, or smoking for at least 30 minutes before testing to prevent false results. Saliva contains enzymes and food residues that could affect accuracy.
Will this test show if I’ve used opioids long-term?
No, this test measures recent use only. For long-term opioid exposure, blood or urine tests may be needed, as they detect metabolites that linger in the body longer.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy