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Oxycodone and Oxymorphone Concentration in Blood (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of two opioid pain relievers—oxycodone and oxymorphone—in your blood. It helps determine if you’ve recently used these medications.

Quick summary

["This screening checks for opioids that may affect your pain management or response to treatment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77731-8
Short code
oxyCODONE+oxyMORphone SerPlBld Cfm-Imp
Synonyms
oxyCODONE+oxyMORphone SerPlBld Cfm-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’ve been prescribed oxycodone or oxymorphone, if you’re experiencing suspected opioid use, or if you’re undergoing monitoring for substance use. It can also be part of a broader drug screening, especially in medical settings like hospitals or rehab programs.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or vein to draw blood. The process takes a few minutes, and you may feel a brief pinch. If you’re concerned about needles, let your provider know.

What the Results Mean

Positive results indicate recent opioid use, which may impact your medication levels or overall health. Negative results mean these opioids were not detected in your system at the time of testing. Always discuss results with your healthcare provider.

Common Reasons for Testing

This test helps ensure safe dosing of opioids, assesses compliance with treatment plans, or identifies unintended exposure. It’s also used in legal or workplace settings where drug testing is required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Drug Screen (Opioids)

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your provider will contact you once they’re ready.
Can I drink alcohol before this test?
No, avoid alcohol for 24 hours before testing, as it may interfere with lab results or cause discomfort during blood draw.
Will this test show if I’ve used opioids long-term?
This test screens for recent opioid exposure, not long-term use. For chronic use, additional tests or urine samples may be needed to assess accumulation in the body.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy