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Oxycodone Concentration in Saliva (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of oxycodone, a pain medication, in your saliva. It helps assess recent drug use.

Quick summary

["This test checks for recent oxycodone exposure through saliva, useful for monitoring pain management or substance use."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74657-8
Short code
oxyCODONE Sal Ql Cfm
Synonyms
oxyCODONE Sal Ql Cfm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you are suspected of recent oxycodone use, experiencing symptoms related to opioid exposure, or as part of a routine screening for substance use. Saliva testing is often used because it reflects recent drug intake more accurately than other specimens.

What to Expect Before the Test

No special preparation is needed. You may brush your teeth and rinse your mouth with water before the test. The test involves collecting a small saliva sample, usually through swabbing your inner cheek.

What the Test Results Mean

Positive results indicate recent oxycodone use, while negative results suggest no detectable levels of the drug. However, results alone should not be used to diagnose substance use without clinical correlation.

Common Reasons for Testing

This test is commonly used in workplace drug screens, legal proceedings, or by healthcare providers to monitor patients on controlled medications for compliance or potential misuse.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Oxycodone in Saliva

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, depending on the laboratory’s processing time. Your healthcare provider will contact you once the results are ready.
Can I eat or drink before the test?
Yes, you can eat and drink normally before the test. Avoid brushing your teeth or rinsing with mouthwash immediately before collection to prevent interference with the sample.
What if I have taken oxycodone recently?
If you have taken oxycodone recently, the test may detect it in your saliva. However, results should be interpreted by your healthcare provider in the context of your medical history and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy